Research use only ✓ COA Semax Spray
Neuropeptides, Sprays

Semax Spray

CAS 80714-61-0 BATCH 202609SXSP20

Semax Spray is the heptapeptide Semax, Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), already in solution: 20 mg in a 20 mL spray bottle. This Semax nasal spray ships against its lot certificate, which confirms identity and measures the concentration.

Original price was: $119.99.Current price is: $83.99.
Quantity

−30% applied

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Verified test results

Every batch, independently verified.

Each batch is analyzed by an independent third-party laboratory before it ships. This is the released report for the size selected above, exactly as the lab issued it.

HYTE Research DivisionIndependent third-party laboratory
Lot
202609SXSP20
Tested
Sep 17, 2026
Labeled
20mL
Measured
1.15mg/mL
2× tested

Full QC panel

2 passed

Identity

HPLC-DAD

Semax confirmedPass

Quantity

Curve Assay · spec NLT 90% of label claim

1.15mg/mLPass

What is in a Semax nasal spray?

The peptide is the same one we sell as a 10 mg lyophilised vial: the ACTH(4-7) fragment Met-Glu-His-Phe joined to a Pro-Gly-Pro tail that resists peptidases, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. The difference is the form. The vial is dry powder; the spray bottle holds 20 mg of Semax dissolved in 20 mL, a nominal 1 mg per mL, so no reconstitution step is involved.

The nasal route is the one the Semax literature mostly uses. The developers’ own review describes intranasal administration in animals and people, and a 2006 kinetics study with tritium-labelled Semax detected labelled material in rat brain two minutes after intranasal application, most of it still intact Semax. That is a feature of the research record, not a recommendation: this bottle is a laboratory reference material.

Semax identity

Names Semax, ACTH(4-7)-Pro-Gly-Pro, ACTH(4-7)PGP; Semax nasal spray
Sequence MEHFPGP (H-Met-Glu-His-Phe-Pro-Gly-Pro-OH)
Molecular formula C37H51N9O10S
Molecular weight 813.9 g/mol
CAS number 80714-61-0
PubChem CID 9811102
This product Solution, 20 mg Semax in 20 mL (nominal 1 mg/mL), spray bottle

This is unmodified Semax. “N-acetyl Semax amidate” is a different molecule (Ac-MEHFPGP-NH2); see the Semax vial page for the difference.

Certificate for the current lot

Every bottle is filled from one lot and ships against that lot’s certificate, issued by HYTE Research Division. Identity is confirmed by HPLC with diode-array detection, and the Semax concentration is measured against a specification of not less than 90% of the label claim:

SizeLotLaboratoryAnalysedMeasured contentIdentity
20mL
202609SXSP20
HYTE Research Division
17 Sep 2026
1.15mg/mL
Semax confirmed

Transcribed from the certificate issued for each size on sale today. Open the signed certificate for any size under Verified test results above. Every Semax Spray COA, lot by lot

The spray certificate reports identity and concentration; it does not report an HPLC purity figure. The 10 mg vial has its own certificate, from ILS Laboratories, with an HPLC purity result.

How Semax has been studied

The clinical Semax literature is Russian, mostly in stroke rehabilitation and mostly in Russian. ClinicalTrials.gov lists no Semax study.

Regulatory status

A 2022 review lists Semax among the peptide products registered in the Russian Federation, as a nootropic. In the US it is not an approved drug; FDA’s compounding safety-risk page lists “Semax (heptapeptide)” among nominated-but-withdrawn substances. Deigin VI, et al. Pharmaceutics, 2022; FDA compounding safety-risk list. Clean Peptide’s Semax Spray is for laboratory research only, not for human or veterinary use.

Related research

Technical specification

What is on file, and how it is handled

Every figure below is transcribed from the paperwork for this compound.

Material

Compound
Semax Spray
Class
ACTH(4-7) analogue (glyproline heptapeptide)
Form
Solution: 20 mg in 20 mL, spray bottle
Sizes
20mL
Sequence
MEHFPGP (H-Met-Glu-His-Phe-Pro-Gly-Pro-OH)
Formula
C37H51N9O10S
CAS
80714-61-0
Mol. weight
813.9 g/mol
Residues
7

Verification

Identity
Confirmed on the certificate of analysis
Purity
See certificate
Batch
202609SXSP20
Documentation
Per-batch certificate of analysis

Handling

Storage
Store at −20 °C, protected from light
Intended use
In-vitro laboratory research only
Compound data on PubChem

QuestionsSemax Spray: frequently asked

What is in the Semax nasal spray?+

20 mg of Semax (MEHFPGP) dissolved in 20 mL, a nominal 1 mg per mL, in a spray bottle. The current lot’s certificate confirms identity by HPLC-DAD and reports the measured concentration.

What is the difference between Semax Spray and the Semax vial?+

Same peptide, different form. The vial is 10 mg of lyophilised powder with an ILS Laboratories certificate that includes HPLC purity; the spray is 20 mg already in solution with a HYTE Research Division certificate for identity and concentration.

Was Semax studied as a nasal spray?+

The published Semax research mostly used intranasal application, in rats and in Russian clinical studies, and a 2006 study tracked labelled Semax into rat brain after intranasal application.

Is this N-acetyl Semax amidate?+

No. This is unmodified Semax, C37H51N9O10S (813.9 g/mol, CAS 80714-61-0). N-acetyl Semax amidate is a separate molecule with an acetylated N-terminus and an amidated C-terminus.

Is Semax FDA-approved?+

No. A 2022 review lists it as registered in Russia as a nootropic. FDA lists Semax among bulk substances nominated, then withdrawn, from its compounding safety-risk category.

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