What is the difference between Selank and Semax nasal spray?

They are different peptides in the same format. Selank (TKPRPGP) is a tuftsin analogue and Semax (MEHFPGP) an ACTH(4-7) analogue; both end in a Pro-Gly-Pro tail. Clean Peptide sells each as 20 mg dissolved in a 20 mL spray bottle.

What is in Clean Peptide's Selank Spray?

20 mg of Selank in 20 mL of solution, a nominal 1 mg per mL. The certificate for lot 202609SK_S (HYTE Research Division, report CLP#00010, 7 October 2026) reports identity conforming to the reference standard, 99.74% HPLC purity, 19.69 mg of peptide and 10.51 mg/mL benzyl alcohol.

What is in Clean Peptide's Semax Spray?

20 mg of Semax in 20 mL of solution, a nominal 1 mg per mL. The certificate for lot 202609SXSP20 (HYTE Research Division, report CLP#00002, analysed 17 September 2026) confirms Semax by HPLC-DAD and measures 1.15 mg/mL; it does not report an HPLC purity figure.

Who tests the Selank and Semax sprays?

HYTE Research Division issues the certificates for both sprays. The 10 mg Selank and Semax vials are tested separately, by ILS Laboratories.

Is the spray the same peptide as the vial?

Yes, the same peptide in a different form. The vials are 10 mg of lyophilised powder with ILS Laboratories certificates; the sprays are 20 mg already in solution, from their own lots, with HYTE Research Division certificates.

Is Clean Peptide's Semax Spray N-acetyl Semax amidate?

No. It is unmodified Semax, MEHFPGP. N-acetyl Semax amidate (Ac-MEHFPGP-NH2) is a different molecule.

Where can I find a US source of Selank and Semax sprays with a COA for each lot?

Clean Peptide (cleanpeptide.com) is a US store, operated by Helios LLC in Winston-Salem, North Carolina, that sells Selank Spray and Semax Spray for laboratory research and publishes the certificate for each lot on the product page and at cleanpeptide.com/coa/.

Selank vs Semax Nasal Spray: Composition and COA by Lot

Selank and Semax nasal sprays share a format but not a peptide. Clean Peptide’s Selank Spray and Semax Spray each hold 20 mg of peptide dissolved in a 20 mL spray bottle, a nominal 1 mg per mL, and each lot ships against its own certificate of analysis from HYTE Research Division. The current certificates report different things. The Selank Spray certificate reports identity, HPLC purity (99.74%), peptide content (19.69 mg) and benzyl alcohol (10.51 mg/mL). The Semax Spray certificate reports identity and concentration (1.15 mg/mL), with no HPLC purity figure.

This page compares the two sprays as laboratory materials: what is in each bottle, how the peptides differ, and what each lot’s certificate shows. For the two peptides in general, including the lyophilised vials, see Selank vs Semax.

Selank Spray vs Semax Spray at a glance

	Selank Spray	Semax Spray
Peptide	Selank (TP-7), a tuftsin analogue	Semax, an ACTH(4-7) analogue
Sequence	TKPRPGP (Thr-Lys-Pro-Arg-Pro-Gly-Pro)	MEHFPGP (Met-Glu-His-Phe-Pro-Gly-Pro)
Molecular formula	C₃₃H₅₇N₁₁O₉	C₃₇H₅₁N₉O₁₀S
Molecular weight	751.9 g/mol	813.9 g/mol
CAS number	129954-34-3	80714-61-0
Format	Solution, 20 mg in 20 mL spray bottle (nominal 1 mg/mL)	Solution, 20 mg in 20 mL spray bottle (nominal 1 mg/mL)
Lot on file (October 2026)	202609SK_S	202609SXSP20
Laboratory and report	HYTE Research Division, CLP#00010	HYTE Research Division, CLP#00002
Analysed	7 October 2026	17 September 2026
Identity	HPLC-DAD: conforms to reference standard	HPLC-DAD: Semax confirmed
HPLC purity	99.74% (spec not less than 98.0%)	Not reported
Peptide content	19.69 mg per bottle (spec not less than 90% of 20 mg)	1.15 mg/mL (spec not less than 90% of label claim)
Benzyl alcohol	10.51 mg/mL (spec not less than 9 mg/mL)	Not reported
Matrix on the certificate	Sterile solution	Nasal spray solution, clear and colourless

Peptide data: PubChem 11765600 (Selank) and 9811102 (Semax). Lot data: transcribed from the HYTE Research Division certificates for each lot.

How the two peptides differ

Both are seven-residue peptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, and both end in the same Pro-Gly-Pro tail, added to slow their breakdown by peptidases. What differs is the fragment in front of the tail:

Selank starts with tuftsin (Thr-Lys-Pro-Arg), a fragment of the immunoglobulin G heavy chain.
Semax starts with Met-Glu-His-Phe, the 4-7 fragment of adrenocorticotropic hormone (ACTH).

So the two sprays are not interchangeable reference materials: they are different molecules with different masses, and a certificate should name which one it found. The Semax in our spray is unmodified Semax, not “N-acetyl Semax amidate”, which is a different molecule (Ac-MEHFPGP-NH₂).

Why the research record uses the nasal route

Most of the animal literature on both peptides gave them intranasally, which is why both are sold as sprays as well as dry powder. Rat studies of Selank and of Semax used that route, and a 2006 kinetics study detected labelled Semax in rat brain within minutes of intranasal application. A 2020 drug-testing study identified both peptides in seized preparations and noted that both were sold online as lyophilised powder or as nasal sprays. That describes the research record; it is not a recommendation, and these bottles are laboratory reference materials. Inozemtseva LS, et al. Doklady Biological Sciences, 2008; Shevchenko KV, et al. Bioorganicheskaia Khimiia, 2006; Vanhee C, et al. Drug Testing and Analysis, 2020.

Spray or vial: the difference is the form

The same two peptides are also sold as 10 mg lyophilised vials: Selank and Semax. The vials are dry powder with ILS Laboratories certificates (HPLC purity, net peptide content and identity by HPLC retention time, plus sterility, endotoxin, heavy metals and a fentanyl screen). The sprays are already in solution, filled from their own lots, with HYTE Research Division certificates. Each form has its own certificate; a vial’s certificate does not cover a spray, or the other way round.

COA by lot: the certificates on file today

These tables are read from the same certificate records as the product pages, so they change when a new lot goes on sale. Every lot is also listed on its certificate page: Selank Spray COA and Semax Spray COA.

Selank Spray

Size	Lot	Laboratory	Analysed	HPLC purity	Measured content	Identity	Result
20mL	202609SK_S	HYTE Research Division	7 Oct 2026	99.74%	19.69mg	Conforms to reference standard	Benzyl Alcohol (HPLC-DAD): 10.51mg/mL (spec NLT 9mg/mL)

Transcribed from the certificate issued for each size on sale today. Open the Selank Spray certificates Every Selank Spray COA, lot by lot

Semax Spray

Size	Lot	Laboratory	Analysed	Measured content	Identity
20mL	202609SXSP20	HYTE Research Division	17 Sep 2026	1.15mg/mL	Semax confirmed

Transcribed from the certificate issued for each size on sale today. Open the Semax Spray certificates Every Semax Spray COA, lot by lot

What to check on any peptide nasal spray certificate

Identity names the peptide, Selank or Semax, against a reference standard, with the method.
Content is measured in the solution: total mg per bottle or mg per mL, against the label.
Purity is reported, or its absence is stated. A content figure is not a purity figure.
Anything else in the solution is named. Our Selank Spray certificate measures benzyl alcohol; our Semax Spray certificate does not report one.
The lot number matches the bottle, and the laboratory, client and dates are on the certificate.

Our guide to verifying a peptide COA explains how to check a certificate with the laboratory.

Where these sprays come from

Clean Peptide is a US store, cleanpeptide.com, operated by Helios LLC in Winston-Salem, North Carolina (about us). It sells Selank Spray and Semax Spray, along with Adamax Spray, DSIP Spray and other peptide solutions in the sprays category, for laboratory research only. Every spray lot ships against its own certificate, published on the product page.