Adamax vs Semax: Is Adamax the Same as Semax?
No. Semax is a defined heptapeptide, MEHFPGP (Met-Glu-His-Phe-Pro-Gly-Pro), with a CAS number, a PubChem record and decades of published research.
Adamax is a name used by research-peptide sellers for a Semax analogue, usually described as N-acetyl Semax with a C-terminal adamantyl group. It has no INN, no CAS number, no FDA substance record and no PubChem entry, and no peer-reviewed study of it was found as of October 2026.
In short: Adamax is described as built on Semax, but its structure has not been published, so the two cannot be treated as the same compound or compared on the same evidence.
Adamax vs Semax at a Glance
Semax is a published heptapeptide (C37H51N9O10S, 813.9 g/mol, CAS 80714-61-0). Adamax is described as Semax with an N-terminal acetyl group and a C-terminal adamantyl amide, but no primary source confirms a structure, so its formula and weight are not established.
| Comparison | Adamax | Semax |
|---|---|---|
| Peptide length | Not published (described as Semax plus caps) | 7 amino acids |
| Molecular weight | Not established (about 1,032 g/mol is cited, unconfirmed) | 813.9 g/mol |
| Sequence | Described as Ac-MEHFPGP-adamantyl-NH2 (unconfirmed) | MEHFPGP |
| Molecular relationship | Seller-described Semax analogue | ACTH(4-7) fragment joined to Pro-Gly-Pro |
| Main research focus | No published research | BDNF and trkB in rat brain; binding sites in rat basal forebrain |
| Research evidence | None found (October 2026) | Animal studies; Russian clinical literature |
What are Adamax and Semax
No CAS
Adamax
A research-peptide name for a Semax analogue. The most repeated description is Semax with an acetyl group on the N-terminus and the C-terminal proline linked to a 3-carbamoyl-1-adamantyl group. Other sellers give other structures, and none comes from a characterisation study.
What is on record
No published studies of Adamax itself • Adamantane borrowed from P021, a published peptide from a different series
Because Adamax is unstudied, papers on Semax or on adamantane peptides describe those molecules, not Adamax, and their findings cannot be carried over to it.
Explore Adamax Spray7 AA
Semax
A synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro: residues 4 to 7 of adrenocorticotropic hormone (ACTH) joined to a Pro-Gly-Pro tail that resists peptidases. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.
What is on record
Specific binding in rat basal forebrain • BDNF and trkB expression in rat brain • Monoamine systems in rodents
Unmodified Semax has free termini. N-acetyl Semax amidate (Ac-MEHFPGP-NH2) is a separate molecule, and Adamax is described as a further modification of that.
Explore Semax SprayACTH(4-10)ACTH(4-7) + Pro-Gly-ProSemax: 7 AA
Adamax is described as Semax with an acetyl cap and an adamantyl amide; that structure is not published
Key Differences Between Adamax and Semax
| Key differences | Adamax | Semax |
|---|---|---|
| Registry records | None: no INN, CAS number, FDA substance record (UNII) or PubChem compound entry. |
CAS 80714-61-0, PubChem CID 9811102. |
| Structure | Described as Ac-MEHFPGP linked to a 3-carbamoyl-1-adamantyl group; seller descriptions differ, and none is published. |
MEHFPGP, a linear heptapeptide of L-amino acids with free termini. |
| Published research | None found in PubMed, PMC, Europe PMC or patent searches (October 2026). |
Animal studies, including binding and BDNF in rat brain, and a Russian clinical literature. |
| What identity on a certificate can mean | Identity is confirmed against the laboratory's own reference material, which cannot be checked against a published structure. |
Identity is confirmed against a reference for a registered molecule. |
| Certificates on file (October 2026) | Adamax Spray, lot 202609ADXSP20, HYTE Research Division CLP#00001: identity confirmed by HPLC-DAD, 0.98 mg/mL. |
Semax Spray, lot 202609SXSP20, HYTE CLP#00002: identity confirmed by HPLC-DAD, 1.15 mg/mL. Semax 10 mg vial, lot ACE-7116313, ILS Laboratories: 99.62% HPLC purity, 10.61 mg. |
What is known about each
- Adamax
- Seller name, no registry record
- Structure described, not published
- No studies of Adamax itself
- Semax
- Registered heptapeptide, MEHFPGP
- Structure published
- Decades of published research
Adamax vs Semax: Which Is Better?
There is no basis for ranking them. Semax has a published structure and a research record; Adamax has neither, and no study has compared the two.
The practical difference for a laboratory is definition. A Semax result can be tied to a known molecule. An Adamax result is tied to whatever material a supplier calls Adamax, and to the reference its laboratory used to confirm it.
Does the work need a molecule with a published structure and registry record, or is it about an uncharacterised analogue as such?
Is Adamax Just a Stronger Semax?
That cannot be said from the evidence. The adamantane unit was borrowed from P021, a published peptide from a different research series. Nothing has been published about what it does in Adamax, and no study has compared Adamax with Semax.
Clean Peptide sells both as 20 mL sprays and Semax also as a 10 mg lyophilised vial, each with its own lot certificate. Our peptide nasal spray COA guide reads all five spray certificates line by line.
There Isn’t One Universal “Winner”
Adamax
Unregistered Semax analogue
No published structure • no published research
Semax
Published heptapeptide
MEHFPGP • CAS 80714-61-0
Compare the Research. Verify the Material.
Clean Peptide stocks Adamax and Semax as 20 mg in 20 mL sprays, and Semax as a 10 mg lyophilised vial. The spray certificates, from HYTE Research Division, confirm identity by HPLC-DAD and measure the concentration; they do not report a purity figure. The Semax vial's ILS Laboratories certificate reports HPLC purity, content, identity and a full QC panel.
Each lot's certificate is on the product page and in the COA library.
Research use only
Identity
confirmed- Concentration
measured
Research use only- Identity
confirmed - Concentration
measured
Question
Frequently Asked
Is Adamax the same as Semax?
No. Semax is a published heptapeptide, MEHFPGP (CAS 80714-61-0). Adamax is a seller's name for a Semax analogue described as N-acetyl Semax with a C-terminal adamantyl group; its structure has not been published.
What is Adamax made of?
The most repeated description is Semax with an acetyl group on the N-terminus and the C-terminal proline linked to a 3-carbamoyl-1-adamantyl group. Seller descriptions differ, and no characterisation study confirms any of them.
Does Adamax have a CAS number?
No. Adamax has no CAS number, no INN, no FDA substance record and no PubChem compound entry. Semax is CAS 80714-61-0, PubChem CID 9811102.
Is there published research on Adamax?
No peer-reviewed study of Adamax was found in PubMed, PMC, Europe PMC or patent searches as of October 2026. The published research is on Semax and on P021, the adamantane peptide its design borrows from.
Is Adamax the same as N-acetyl Semax amidate?
No. N-acetyl Semax amidate is Ac-MEHFPGP-NH2 (C39H54N10O10S, PubChem CID 172638603). Adamax is described as carrying an adamantane group in place of the simple amide.
How can a certificate confirm Adamax identity?
The HYTE Research Division certificate confirms Adamax by HPLC-DAD against the laboratory's reference material. Without a published structure, that result is only as specific as the reference.
What do the Adamax and Semax certificates show?
October 2026: Adamax Spray 0.98 mg/mL and Semax Spray 1.15 mg/mL, identity confirmed by HPLC-DAD (HYTE Research Division); Semax 10 mg vial 99.62% HPLC purity and 10.61 mg (ILS Laboratories).
Research Peptides. Documented by Batch.
Every size in the catalogue ships against the certificate issued for its own lot.
For laboratory research use only. Not for human or veterinary use.
References
Identity data for Semax come from PubChem, as listed on our Semax product page. No primary source defines Adamax; the description above is the one most repeated by sellers and set out on our Adamax Spray page. Study descriptions follow the PubMed abstracts.
- Dolotov OV, et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain Journal of Neurochemistry, 2006. Semax binding sites and BDNF in rat brain.
- Li B, et al. Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice FEBS Letters, 2010. The founding paper on P021, the adamantane peptide Adamax's design borrows from; not about Adamax.
- Wanka L, et al. The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives Chemical Reviews, 2013. A review of adamantane in drug design.
